Juniper Publishers Gynecology and Women’s Health

      JUNIPER PUBLISHERS- JOURNAL OF GYNECOLOGY AND WOMEN’S HEALTH                                 Journal of Gynecology and Women’s Health-Juniper Publishers   Authored by Daria M Lukyanova*   Introduction Genital prolapse (GP) is a serious problem with high prevalence among the female population. It is due to adjacent organ dysfunction and a high rate of relapse after surgical treatment. The prevalence of GP varies from 4.5 to 30%. The risk factors of GP, such as increased abdominal pressure, difficult delivery, altered hormone imbalance, lead to abnormal remodeling of extracellular matrix. This disorder changes the normal architectonics and mechanical properties of pelvic floor tissues [ 1 ]. There is a hereditary predisposition to PG in 33% of cases. Genital prolapse is often accompanied by other clinical manifestations of connective tissue dysplasia [ 2 ]. The identification of genetic polymorphisms determining predisposition to GP are important.