Juniper Publishers : Uterine Serous Carcinoma; Molecular Pathways and Role of Micrornas in Early Detection and Target Therapy
JUNIPER PUBLISHERS- JOURNAL OF GYNECOLOGY AND WOMEN’S HEALTH Journal of Gynecology and Women’s Health-Juniper Publishers Authored by Shiva Rezaei* Abstract Uterine serous carcinoma (USC) in association with endometrial clear cell carcinoma (CCC) and grade 3 endometrioid carcinoma is responsible for 70-75% of endometrial carcinoma deaths and per se accounts for 39% of this cancer related mortality. Its tendency for early spread, leads to upstaging of 50-70% of clinically stage I cancers at the time of operation. Involved molecular pathway(s) in this cancer differ from those of conventional endometriod carcinoma. It has been accepted that P53 mutation occurs as an early event in the endometrial serous carcinogenesis. Findings of P53 signature in the endometria...