Juniper Publishers Gynecology and Women’s Health

              JUNIPER PUBLISHERS- JOURNAL OF GYNECOLOGY AND WOMEN’S HEALTH                                  Journal of Gynecology and Women’s Health-Juniper Publishers   Authored by  Ushkalova EA   Introduction Paracetamol (acetaminophen) is the most widely used medicine in pregnancy [ 1 ]. Large surveys have reported that 4065% of women take this drug sometime during their gestation [ 2 , 3 ]. Even though paracetamol is considered the safest analgesic and antipyretic medicine, its improper use in pregnancy may lead to serious consequences to mother and fetus/child. Paracetamol safety concerns in pregnancy Paracetamol is a drug with a narrow therapeutic index causing potentially fatal liver damage in overdose. Pregnant women may be more vulnerable to hepatotoxic reactions due to a change in the metabolism of the drug [ 4 ]. Increased activity of oxidative pathways of paracetamol metabolism during pregnancy contributes to the formation of toxic NAPQI metabolite [ 5