Juniper Publishers Gynecology and Women’s Health

    JUNIPER PUBLISHERS- JOURNAL OF GYNECOLOGY AND WOMEN’S HEALTH   Journal of Gynecology and Women’s Health-Juniper Publishers   Authored by Zhen-Gao Sun*   Abstract Objective: To explore the effect of controlled ovarian hyperstimulation (COH) on endometrial receptivity of mouse. Methods: Sexually matured Kunming Mice were randomized to a study group (COH group) and a control group. The endometrium in both groups was removed respectively on pregnant day (PD) 0, 2, 4, 6 and 8 for detection of the temporal sequence of the mRNA expression of integrin-β3 and its ligand osteopontin (OPN) in the endometrium by using in situ hybridization method. Results: (1) On the second day of pregnancy, the endometrial integrin-β3 mRNA expression in the study group was significantly higher than that in the control group (P<0.01), while on pregnant day 4 and 6, it is much lower in the study group (P<0.05). There was even no significant difference (P>0.05) when it comes to preg